Synonyms  Creatine kinase M-type, EC 2.7.3.2, Creatine kinase M chain, M-CK, CKM, CKMM. 

Introduction  The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle''s disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creatine Kinases. 

Description  Human CKM produced in Human Cardiac Tissues having a molecular mass of 82 kDa and PI 5.0-7.5. It’s the skeletal muscle specific creatine kinase and is elevated in case of strenuous exercise and in degenerative muscle disease. 

Source  Human Cardiac Tissues 

Physical Appearance  Sterile Filtered clear solution. 

Formulation The CKM protein solution is in 50mM Tris and 2mM DTT, pH 7.5 containing 50% Glycerol. 

Stability  CKM although stable at 14°C for 1 week, should be stored at 2°-8°C. 

Purity Greater than 50.0%.